ARKAS POLYPHENOLIC

Super-Food Supplement

Highest polyphenols 

concentrate for medicinal use, "OLYMPIA" variety

POLYPHENOLIC EVOO

HEALTH PRODUCT

Olive oils containing > 5mg of polyphenols per 20 gr belong to the category of olive oils with "health claims" and protect blood lipids from oxidative stress. Our olive oil contains four times the amount of polyphenols than the above-mentioned average values ​​according to Regulation 432/2012 of the European Union.

Instructions for use:

According to regulation 432/2012 of the European Union, a daily dose of 20g of olive oil contains 250mg/kg of polyphenols and is sufficient to offer protection to the human body against oxidative stress. The daily dose can be obtained by simply drinking 5ml from the 150ml bottle of ARKAS POLYPHENOLIC Food Supplement. We can also get our daily dose by eating Mediterranean diet meals (salads, fish, fruits, vegetables) and adding to them extra virgin olive oil rich in polyphenols. With the addition of raw 150ml ARKAS POLYPHENOLIC Food Supplement, we can enjoy a wonderful taste while absorbing its valuable protective properties.

Olive oil polyphenols ​ Olive oil polyphenols help protect blood lipids from oxidative stress.

 

The claim may only be used for olive oil which contains at least 5 mg of hydroxytyrosol and its derivatives (eg complex of oleoeuropein and tyrosol) per 20 g of olive oil. In order to use this claim, the information should be provided to the consumer that the beneficial effects are ensured with a daily intake of 20 g of olive oil. ​

 

EFSA Journal no Relevant entry number in the consolidated list submitted to EFSA for assessment:

2011·9(4):2033

1333, 1638,

1639, 1696,

2865

Health Benefits

The beneficial properties of olive oil that have been scientifically proven by clinical studies:

Protection of the heart system.

Olive oil has cardioprotective benefits due to its strong antioxidant action that helps clean the lipids from the arteries. Chronic exposure to low doses of antioxidants/anti-inflammatory substances, such as oleocanthal contained in olive oil, offers protection against cardiovascular disease.

Diabetes

Protection against Type 2 Diabetes by helping to reduce blood glucose levels.

Arthritis

Contribute to the prevention and treatment of rheumatoid arthritis and other types of inflammatory arthritis as it reduces the synthesis of nitric oxide, which is associated with the destruction of cartilage. There is enough evidence that the oleic acid found in abundance in olive oil alone reduces inflammatory markers such as C-reactive protein.

Cholesterol reduction

Contributing to the reduction of LDL cholesterol levels and the treatment of atherosclerosis while at the same time contributing to the increase of HDL cholesterol levels.

​Vitamin E

​Protection from oxidative stress as olive oil is rich in vitamin E.

Antithrombotic action.

Olive oil acts as an antithrombotic drug, as it has anti-inflammatory properties and inhibits the COX and LOX enzymes that cause the process of platelet aggregation and consequently inhibit the formation of clots in the vessels.

Neuroprotective benefits

Protection of cells and DNA from damage, multiple sclerosis, and malignant melanoma - Protective effect against Alzheimer's disease (Research has shown the inhibition of the progression of Alzheimer's disease in laboratory animals)

Anti-cancer benefits

In particular, oleocanthalia (OLC), a phenolic compound from extra virgin olive oil, has been shown to exhibit anticancer activity in various tumor models.

Contributes to skin health

It contributes to the health of the skin, as it protects it from ultraviolet radiation and has an anti-aging effect due to antioxidant/anti-inflammatory substances contained in it.

Benefits against pancreatitis

Prevents acute pancreatitis

Digestive system benefits

Protection in the digestive system (reducing the likelihood of ulcers) & in the gastrointestinal system (improving colon motility, constipation)

Osteoporosis

Protection against osteoporosis and rheumatoid arthritis

Blood Pressure & Ischemic Episodes

Protection against the occurrence of an ischemic stroke and contribution to the reduction of blood pressure

The beneficial elements of our Polyphenolic EVOO Food Supplement

A NATURAL ANTI-INFLAMMATORY SUBSTANCE

The extra virgin olive oil that has been produced contains oleocanthal, a compound that causes a stinging sensation in the throat, similar to the sensation that occurs when taking ibuprofen, a powerful anti-inflammatory drug. According to this study, oleocanthal inhibits specific enzymes associated with inflammation, actually showing an action equivalent to ibuprofen.

REDUCES THE RISK OF THROMBOSIS (BLOOD CLOTTING)

The content of olive oils in phenols can positively affect the cardiovascular system. A study has been carried out where the participants consumed 40 ml of extra virgin olive oil, with a known number of phenols, in order to evaluate the effects on the function of platelets, a component of the blood that is related to its persuasion. The resulting results were compared to the action of ibuprofen, a strong anti-inflammatory substance. From the study it appeared that the olive oils that were rich in oleocanthal and oleasin caused a greater than 25% reduction in the maximum aggregation of blood platelets, the main cause for the formation of blood clots.

HIGH PHENOLIC OLIVE OILS HAVE BEEN ASSOCIATED WITH SIGNIFICANT IMPROVEMENT OF MENTAL FUNCTIONING IN PEOPLE WITH EARLY SYMPTOMS OF ALZHEIMER'S DISEASE

For the first time, high phenolic olive oils rich in oleocanthal and oleasin were associated with a significant improvement of mental functions in humans. The effect of daily intake of high phenolic olive oils was found to be dose dependent in accordance with the concentration of phenolic compounds. The positive results were achieved within three months.

PROTECTION FROM ALZHEIMER'S DISEASE

According to the results of the study by Pitt and his colleagues, even low doses of oleocanthal protect neurons and could possibly serve as a basis for Alzheimer's disease treatments in the future.

CAUSES THE DEATH OF CANCER CELLS ONLY AND NOT NORMAL CELLS

The experiments of LeGendre and colleagues showed that oleocanthal causes the death of cancer cells within 30 minutes and does not affect healthy cells.

THE ROLE OF OLEOCANTHAL IN BREAST AND PROSTATE CANCER

In the study by Enagar and his team, it was shown that oleocanthal, at the cellular level, inhibits the growth and the potential for metastasis of breast or prostate cancer cells, even in small amounts, oleocanthal has a powerful therapeutic role in breast and prostate cancer .

THE ACTION OF OLEOCANTHALI AGAINST BREAST CANCER

Experiments were done to inhibit the growth of breast cancer cells with the addition of oleocanthal in very small concentrations. The results showed that indeed oleocanthal half inhibits the action of a protein that plays an important role in the growth of cancer cells and by extension also breast cancer.

ANTI-CANCER PROPERTIES IN HEPAR - LIVER

The study by Pei and his colleagues showed that oleocanthal reduced the proliferation of liver cancer cells and inhibited the growth of the tumor. It also prevented metastasis in lung cells. These results give hope for the use of oleocanthal for therapeutic purposes.

ANTI-CANCER ACTIVITY IN THE HEPAR AND COLON

A study showed that oleocanthal can have an anti-inflammatory and anti-cancer effect on cancer cells of the liver and colon. The results show that it inhibits the growth of cancer while having no effect on normal cells.

BENEFICIAL ACTION IN MALIGNANT MELANOMA OF THE SKIN

Experiments have shown that oleocanthal has a remarkable effect on melanoma cells against normal skin cells even at very low concentrations.

THE EFFECT OF DIETARY INTERVENTION WITH OLIVE OIL HIGH IN OLEOCANTHAL AND OLECEIN IN A PATIENT WITH EARLY STAGE CHRONIC LYMPHOCYTIC LEUKEMIA.

Oleacin is one of the strongest inhibitors of 5-lipoxygenase, an enzyme associated with the first stages of inflammation. Its action is stronger than that of oleocanthal and eleuropein, a fact that makes the production of anti-inflammatory medicine based on oleosein useful.

OLEACEIN REDUCES THE PATHOGENESIS OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS THROUGH ITS ANTIOXIDANT AND ANTI-INFLAMMATORY ACTION.

Daily consumption of extra-virgin early-harvest olive oil - (virgin olive oil) with a certified high content of phenols and especially oleic acid, forms a protective shield for the central nervous system and possibly protects against the worsening of the symptoms of plaque sclerosis.

STRONG ANTI-INFLAMMATORY ACTION

Rigacci S and colleagues examined the effects on amylin aggregation and cytotoxicity of eleuropein salt. Amylin is a substance quite similar to insulin. When amylin accumulates in pancreatic cells, it creates amyloid which is directly related to the pathogenesis of type II diabetes. Oleoeuropein aglycone inhibits amylin accumulation and pancreatic cell toxicity. These results provide a molecular basis for some of the potential benefits of extra virgin olive oil consumption and pave the way for the development of new inhibitors.

MAY PROTECT FROM ISCHEMIC STROKE

The results of experiments show that oleic acid has the ability to weaken the destabilization of carotid plaques and may be useful in reducing the risk of an ischemic episode.

PROTECTION AGAINST RED CELL DESTRUCTION

The Pavla-Martins study showed that the antioxidant activity of oleasin in erythrocytes was very strong not only when administered in high doses but also in lower ones.

HELPS TREAT ATHEROSCLEROSIS

Olive oil can play an important role in reducing the progression of atherosclerosis, which is the most important cause of stroke or heart attack. Its antioxidant, anti-inflammatory, anti-cancer and antimicrobial activity has already been experimentally verified, but further studies are required regarding the treatment of atherosclerosis.

PROTECTS CELLS FROM AGING

In the study by Parzonko and his team, it was studied to what extent oleacein can protect cells from aging and their death. The experiments showed that the cells exposed to oleasin proliferated significantly in proportion to the dosage.

ANTI-INFLAMMATORY ACTION AND ITS MECHANISMS

The experiments of Filipek and his colleagues showed that oleacein can play an inhibitory role in the inflammation associated with atherosclerosis. In particular, oleasin either unites with specific components of the blood and causes the stimulation of producers of two special anti-inflammatory proteins, or it causes the production of another protein related to inflammation within the cells.

THE ​​LIGUSTROSIDE AGLYCONE AGAINST BREAST CANCER METASTASIS.

In the study by Busnena and colleagues, the ​ligustroside aglycone showed better replacement activity in experiments performed on highly metastatic human breast cancer cells. Due to its special chemical structure, it inhibits the activity of a specific protein, the c-MET protein, which is related to the development of malignant tumors

THE EFFECT OF ​LIGUSTROSIDE AGLYCONE ON MECHANISMS RELATED TO BREAST CANCER DEVELOPMENT

Menendez and his team in their study investigated the ability of ​ligustroside aglycone to regulate the receptor tyrosine kinase HER2, which is present in large amounts in breast cancer cells and causes them to proliferate uncontrollably. ​ligustroside aglycone was one of the most active inhibitors of HER2 expression in cells, with a 68% reduction even with very small doses, leading cancer cells to programmed cell death. These findings provide an excellent and safe platform for the design of new drugs for breast cancer.

THE BENEFICIAL EFFECT OF OLEUROPEIN AGAINST TYPE II DIABETES

Rigacci S and colleagues examined the effects on amylin aggregation and cytotoxicity of eleuropein salt. Amylin is a substance quite similar to insulin. When amylin accumulates in pancreatic cells, it creates amyloid which is directly related to the pathogenesis of type II diabetes. Oleoeuropein aglycone inhibits amylin accumulation and pancreatic cell toxicity. These results provide a molecular basis for some of the potential benefits of extra virgin olive oil consumption and pave the way for the development of new inhibitors.

EXPERIMENTS IN MICE SHOW THE ACTIVE ACTION OF OLEUROPEIN AGLYCUS IN THE DEVELOPMENT OF ALZHEIMER'S DISEASE

The research of Grossi and his colleagues in mice showed that the dietary supplement of 50 mg/kg of aglycoe aleuropein for 8 weeks not only showed a significant improvement in the cognitive ability of the mice but also a stabilization of the progression of the disease.

Academic Research for Polyphenols

• Diamantakos P, Ioannidis K, Papanikolaou C, Tsolakou A, Rigakou A, Melliou E, Magiatis P. A New Definition of the Term “High-Phenolic Olive Oil” Based on Large Scale Statistical Data of Greek Olive Oils Analyzed by qNMR. Molecules. 2021; 26: 1115.

https://www.mdpi.com/1420-3049/26/4/1115/htm

• Rojas Gil1 A. P, Kodonis I, Ioannidis A, Nomikos T, Dimopoulos I, Kosmidis G, Katsa M EMelliou E, Magiatis P. The Effect of Dietary Intervention With High-Oleocanthal and Oleacein Olive Oil in Patients With Early-Stage Chronic Lymphocytic Leukemia: A Pilot Randomized Trial 2022; Front. Oncol., 21 January 2022

https://www.frontiersin.org/articles/10.3389/fonc.2021.810249/full • The European Commission. REGULATIONS, COMMISSION REGULATION (EU) No 432/2012.

• Batarseh YS , Mohamed LA, Al Rihani SB, Mousa YM, Siddique AB, El Sayed KA, Kaddoumi A. Oleocanthal ameliorates amyloid-β oligomers' toxicity on astrocytes and neuronal cells: In vitro studies. Neuroscience. 2017; 352: 204-215.

• Beauchamp GK, Keast RSJ, Morel D, Lin J, Pika J, Han Q, Lee CH, Smith AB, Breslin PAS.

• Mrduljaš N, Krešić G, Bilušić T. Polyphenols: Food Sources and Health Benefits. . Functional Food - Improve Health through Adequate Food. 2017.

• Phytochemistry: ibuprofen-like activity in extra-virgin olive oil. Nature. 2005; 437(7055): 45- 6.

• Gorzynik-Debicka M, Przychodzen P, Cappello F, Kuban-Jankowska A, Gammazza AM, Knap N, Wozniak M, Gorska-Ponikowska M. Potential Health Benefits of Olive Oil and Plant Polyphenols. Int. J. Mol. Sci. 2018; 19: 547.

• Naruszewicz M, Czerwińska ME, Kiss AK. Oleacein. Translation from Mediterranean Diet to Potential Antiatherosclerotic Drug. Current Pharmaceutical Design, 2015; 21.

• Official Journal of the European Union. 2012; 136/1-40.

• Parzonko A, Czerwinska ME, Kiss AK, Naruszewicz M. Oleuropein and oleacein may restore biological functions of endothelial progenitor cells impaired by angiotensin II via activation of Nrf2/heme oxygenase-1 pathway. Phytomedicine. 2013; 20(12): 1088-94.

• Perez-Jimenez J, Neveu V, Vos F, Scalbert A. Identification of the 100 richest dietary sources of polyphenols: an application of the Phenol-Explorer database. European Journal of Clinical Nutrition. 2010; 64: 112–120.

 

Χρήσιμα ενημερωτικά άρθρα (μη επιστημονικά)

https://europa.eu/youreurope/business/product-requirements/food-labelling/health nutrition-claims/index_el.htm

https://www.onmed.gr/diatrofi/story/359777/elaiolado-4-idiotites-poy-epivalloyn-tin kathimerini-katanalosi-toy

https://medlabgr.blogspot.com/2012/11/blog-post_26.html#gsc.tab=0https://healthia.gr/elaiolado-diatrofiki-axia-idiotites-kai-ofeli/

https://www.iatropedia.gr/ygeia/i-magikes-therapeftikes-idiotites-tou-ellinikou eleoladou/28946/

https://www.mednutrition.gr/portal/efarmoges/leksiko-diatrofis/12775-omo-elaiolado polytimo-gia-tin-ygeia-kai-gia-tin-kouzina-mas

https://www.ypaithros.gr/sinaspizontai-oi-ellines-paragwgoi-elaioladwn-me igeioprostateutiki-drasi/

https://www.dimotikiagoratislakonias.gr/epikairotita/ygeia/item/41964-ta-apotelesmata klinikis-meletis-me-elaiolado-sto-nosokomeio-spartis

https://bit.ly/3x6I8u4