ARKAS POLYPHENOLIC
Super-Food Supplement
HEALTH CLAIM:
The claim may only be used for olive oil containing at least 5 mg of hydroxytyrosol and its derivatives (e.g. oleoeuropein complex and of tyrosol) per 20 g of olive oil. To use o this claim, should be provided to the consumer n information that beneficial effects occur with the daily intake of 20 g of olive oil
Olive oil polyphenols Olive oil polyphenols help protect blood lipids from oxidative stress.
The claim may only be used for olive oil which contains at least 5 mg of hydroxytyrosol and its derivatives (eg complex of oleoeuropein and tyrosol) per 20 g of olive oil. In order to use this claim, the information should be provided to the consumer that the beneficial effects are ensured with a daily intake of 20 g of olive oil.
EFSA Journal no Relevant entry number in the consolidated list submitted to EFSA for assessment:
2011·9(4):2033
1333, 1638,
1639, 1696,
2865
Health Benefits
The beneficial properties of olive oil that have been scientifically proven by clinical studies:
Protection of the heart system.
Olive oil has cardioprotective benefits due to its strong antioxidant action that helps clean the lipids from the arteries. Chronic exposure to low doses of antioxidants/anti-inflammatory substances, such as oleocanthal contained in olive oil, offers protection against cardiovascular disease.
Diabetes
Protection against Type 2 Diabetes by helping to reduce blood glucose levels.
Arthritis
Contribute to the prevention and treatment of rheumatoid arthritis and other types of inflammatory arthritis as it reduces the synthesis of nitric oxide, which is associated with the destruction of cartilage. There is enough evidence that the oleic acid found in abundance in olive oil alone reduces inflammatory markers such as C-reactive protein.
Cholesterol reduction
Contributing to the reduction of LDL cholesterol levels and the treatment of atherosclerosis while at the same time contributing to the increase of HDL cholesterol levels.
Vitamin E
Protection from oxidative stress as olive oil is rich in vitamin E.
Antithrombotic action.
Olive oil acts as an antithrombotic drug, as it has anti-inflammatory properties and inhibits the COX and LOX enzymes that cause the process of platelet aggregation and consequently inhibit the formation of clots in the vessels.
Neuroprotective benefits
Protection of cells and DNA from damage, multiple sclerosis, and malignant melanoma - Protective effect against Alzheimer's disease (Research has shown the inhibition of the progression of Alzheimer's disease in laboratory animals)
Anti-cancer benefits
In particular, oleocanthalia (OLC), a phenolic compound from extra virgin olive oil, has been shown to exhibit anticancer activity in various tumor models.
Contributes to skin health
It contributes to the health of the skin, as it protects it from ultraviolet radiation and has an anti-aging effect due to antioxidant/anti-inflammatory substances contained in it.
Benefits against pancreatitis
Prevents acute pancreatitis
Digestive system benefits
Protection in the digestive system (reducing the likelihood of ulcers) & in the gastrointestinal system (improving colon motility, constipation)
Osteoporosis
Protection against osteoporosis and rheumatoid arthritis
Blood Pressure & Ischemic Episodes
Protection against the occurrence of an ischemic stroke and contribution to the reduction of blood pressure
The beneficial elements of our Polyphenolic EVOO Food Supplement
A NATURAL ANTI-INFLAMMATORY SUBSTANCE
The extra virgin olive oil that has been produced contains oleocanthal, a compound that causes a stinging sensation in the throat, similar to the sensation that occurs when taking ibuprofen, a powerful anti-inflammatory drug. According to this study, oleocanthal inhibits specific enzymes associated with inflammation, actually showing an action equivalent to ibuprofen.
REDUCES THE RISK OF THROMBOSIS (BLOOD CLOTTING)
The content of olive oils in phenols can positively affect the cardiovascular system. A study has been carried out where the participants consumed 40 ml of extra virgin olive oil, with a known number of phenols, in order to evaluate the effects on the function of platelets, a component of the blood that is related to its persuasion. The resulting results were compared to the action of ibuprofen, a strong anti-inflammatory substance. From the study it appeared that the olive oils that were rich in oleocanthal and oleasin caused a greater than 25% reduction in the maximum aggregation of blood platelets, the main cause for the formation of blood clots.
HIGH PHENOLIC OLIVE OILS HAVE BEEN ASSOCIATED WITH SIGNIFICANT IMPROVEMENT OF MENTAL FUNCTIONING IN PEOPLE WITH EARLY SYMPTOMS OF ALZHEIMER'S DISEASE
For the first time, high phenolic olive oils rich in oleocanthal and oleasin were associated with a significant improvement of mental functions in humans. The effect of daily intake of high phenolic olive oils was found to be dose dependent in accordance with the concentration of phenolic compounds. The positive results were achieved within three months.
PROTECTION FROM ALZHEIMER'S DISEASE
According to the results of the study by Pitt and his colleagues, even low doses of oleocanthal protect neurons and could possibly serve as a basis for Alzheimer's disease treatments in the future.
CAUSES THE DEATH OF CANCER CELLS ONLY AND NOT NORMAL CELLS
The experiments of LeGendre and colleagues showed that oleocanthal causes the death of cancer cells within 30 minutes and does not affect healthy cells.
THE ROLE OF OLEOCANTHAL IN BREAST AND PROSTATE CANCER
In the study by Enagar and his team, it was shown that oleocanthal, at the cellular level, inhibits the growth and the potential for metastasis of breast or prostate cancer cells, even in small amounts, oleocanthal has a powerful therapeutic role in breast and prostate cancer .
THE ACTION OF OLEOCANTHALI AGAINST BREAST CANCER
Experiments were done to inhibit the growth of breast cancer cells with the addition of oleocanthal in very small concentrations. The results showed that indeed oleocanthal half inhibits the action of a protein that plays an important role in the growth of cancer cells and by extension also breast cancer.
ANTI-CANCER PROPERTIES IN HEPAR - LIVER
The study by Pei and his colleagues showed that oleocanthal reduced the proliferation of liver cancer cells and inhibited the growth of the tumor. It also prevented metastasis in lung cells. These results give hope for the use of oleocanthal for therapeutic purposes.
ANTI-CANCER ACTIVITY IN THE HEPAR AND COLON
A study showed that oleocanthal can have an anti-inflammatory and anti-cancer effect on cancer cells of the liver and colon. The results show that it inhibits the growth of cancer while having no effect on normal cells.
BENEFICIAL ACTION IN MALIGNANT MELANOMA OF THE SKIN
Experiments have shown that oleocanthal has a remarkable effect on melanoma cells against normal skin cells even at very low concentrations.
Academic Literature:
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Low dosages of oleocanthal prove to be protective against Alzheimer’s disease.
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Olive oil rich in oleocanthal effects the cardiovascular system’s function.
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Oleocanthal promotes only the death of cancer cells and not of normal cells.
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Oleocanthal’s anticancer activity in cutaneous malignant melanoma.
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Anticancer effects of oleocanthal in hepatocellular (HCC) and colorectal carcinoma (CRC).
OLEOCANTHAL
THE EFFECT OF DIETARY INTERVENTION WITH OLIVE OIL HIGH IN OLEOCANTHAL AND OLECEIN IN A PATIENT WITH EARLY STAGE CHRONIC LYMPHOCYTIC LEUKEMIA.
Oleacin is one of the strongest inhibitors of 5-lipoxygenase, an enzyme associated with the first stages of inflammation. Its action is stronger than that of oleocanthal and eleuropein, a fact that makes the production of anti-inflammatory medicine based on oleosein useful.
OLEACEIN REDUCES THE PATHOGENESIS OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS THROUGH ITS ANTIOXIDANT AND ANTI-INFLAMMATORY ACTION.
Daily consumption of extra-virgin early-harvest olive oil - (virgin olive oil) with a certified high content of phenols and especially oleic acid, forms a protective shield for the central nervous system and possibly protects against the worsening of the symptoms of plaque sclerosis.
STRONG ANTI-INFLAMMATORY ACTION
Rigacci S and colleagues examined the effects on amylin aggregation and cytotoxicity of eleuropein salt. Amylin is a substance quite similar to insulin. When amylin accumulates in pancreatic cells, it creates amyloid which is directly related to the pathogenesis of type II diabetes. Oleoeuropein aglycone inhibits amylin accumulation and pancreatic cell toxicity. These results provide a molecular basis for some of the potential benefits of extra virgin olive oil consumption and pave the way for the development of new inhibitors.
MAY PROTECT FROM ISCHEMIC STROKE
The results of experiments show that oleic acid has the ability to weaken the destabilization of carotid plaques and may be useful in reducing the risk of an ischemic episode.
PROTECTION AGAINST RED CELL DESTRUCTION
The Pavla-Martins study showed that the antioxidant activity of oleasin in erythrocytes was very strong not only when administered in high doses but also in lower ones.
HELPS TREAT ATHEROSCLEROSIS
Olive oil can play an important role in reducing the progression of atherosclerosis, which is the most important cause of stroke or heart attack. Its antioxidant, anti-inflammatory, anti-cancer and antimicrobial activity has already been experimentally verified, but further studies are required regarding the treatment of atherosclerosis.
PROTECTS CELLS FROM AGING
In the study by Parzonko and his team, it was studied to what extent oleacein can protect cells from aging and their death. The experiments showed that the cells exposed to oleasin proliferated significantly in proportion to the dosage.
ANTI-INFLAMMATORY ACTION AND ITS MECHANISMS
The experiments of Filipek and his colleagues showed that oleacein can play an inhibitory role in the inflammation associated with atherosclerosis. In particular, oleasin either unites with specific components of the blood and causes the stimulation of producers of two special anti-inflammatory proteins, or it causes the production of another protein related to inflammation within the cells.
THE LIGUSTROSIDE AGLYCONE AGAINST BREAST CANCER METASTASIS.
In the study by Busnena and colleagues, the ligustroside aglycone showed better replacement activity in experiments performed on highly metastatic human breast cancer cells. Due to its special chemical structure, it inhibits the activity of a specific protein, the c-MET protein, which is related to the development of malignant tumors
THE EFFECT OF LIGUSTROSIDE AGLYCONE ON MECHANISMS RELATED TO BREAST CANCER DEVELOPMENT
Menendez and his team in their study investigated the ability of ligustroside aglycone to regulate the receptor tyrosine kinase HER2, which is present in large amounts in breast cancer cells and causes them to proliferate uncontrollably. ligustroside aglycone was one of the most active inhibitors of HER2 expression in cells, with a 68% reduction even with very small doses, leading cancer cells to programmed cell death. These findings provide an excellent and safe platform for the design of new drugs for breast cancer.
THE BENEFICIAL EFFECT OF OLEUROPEIN AGAINST TYPE II DIABETES
Rigacci S and colleagues examined the effects on amylin aggregation and cytotoxicity of eleuropein salt. Amylin is a substance quite similar to insulin. When amylin accumulates in pancreatic cells, it creates amyloid which is directly related to the pathogenesis of type II diabetes. Oleoeuropein aglycone inhibits amylin accumulation and pancreatic cell toxicity. These results provide a molecular basis for some of the potential benefits of extra virgin olive oil consumption and pave the way for the development of new inhibitors.
EXPERIMENTS IN MICE SHOW THE ACTIVE ACTION OF OLEUROPEIN AGLYCUS IN THE DEVELOPMENT OF ALZHEIMER'S DISEASE
The research of Grossi and his colleagues in mice showed that the dietary supplement of 50 mg/kg of aglycoe aleuropein for 8 weeks not only showed a significant improvement in the cognitive ability of the mice but also a stabilization of the progression of the disease.
LIGUSTROSIDE AGLYCONE
+ OLEUROPEIN AGLYCONE
Academic Literature:
Academic Research for Polyphenols
• Diamantakos P, Ioannidis K, Papanikolaou C, Tsolakou A, Rigakou A, Melliou E, Magiatis P. A New Definition of the Term “High-Phenolic Olive Oil” Based on Large Scale Statistical Data of Greek Olive Oils Analyzed by qNMR. Molecules. 2021; 26: 1115.
https://www.mdpi.com/1420-3049/26/4/1115/htm
• Rojas Gil1 A. P, Kodonis I, Ioannidis A, Nomikos T, Dimopoulos I, Kosmidis G, Katsa M EMelliou E, Magiatis P. The Effect of Dietary Intervention With High-Oleocanthal and Oleacein Olive Oil in Patients With Early-Stage Chronic Lymphocytic Leukemia: A Pilot Randomized Trial 2022; Front. Oncol., 21 January 2022
https://www.frontiersin.org/articles/10.3389/fonc.2021.810249/full • The European Commission. REGULATIONS, COMMISSION REGULATION (EU) No 432/2012.
• Batarseh YS , Mohamed LA, Al Rihani SB, Mousa YM, Siddique AB, El Sayed KA, Kaddoumi A. Oleocanthal ameliorates amyloid-β oligomers' toxicity on astrocytes and neuronal cells: In vitro studies. Neuroscience. 2017; 352: 204-215.
• Beauchamp GK, Keast RSJ, Morel D, Lin J, Pika J, Han Q, Lee CH, Smith AB, Breslin PAS.
• Mrduljaš N, Krešić G, Bilušić T. Polyphenols: Food Sources and Health Benefits. . Functional Food - Improve Health through Adequate Food. 2017.
• Phytochemistry: ibuprofen-like activity in extra-virgin olive oil. Nature. 2005; 437(7055): 45- 6.
• Gorzynik-Debicka M, Przychodzen P, Cappello F, Kuban-Jankowska A, Gammazza AM, Knap N, Wozniak M, Gorska-Ponikowska M. Potential Health Benefits of Olive Oil and Plant Polyphenols. Int. J. Mol. Sci. 2018; 19: 547.
• Naruszewicz M, Czerwińska ME, Kiss AK. Oleacein. Translation from Mediterranean Diet to Potential Antiatherosclerotic Drug. Current Pharmaceutical Design, 2015; 21.
• Official Journal of the European Union. 2012; 136/1-40.
• Parzonko A, Czerwinska ME, Kiss AK, Naruszewicz M. Oleuropein and oleacein may restore biological functions of endothelial progenitor cells impaired by angiotensin II via activation of Nrf2/heme oxygenase-1 pathway. Phytomedicine. 2013; 20(12): 1088-94.
• Perez-Jimenez J, Neveu V, Vos F, Scalbert A. Identification of the 100 richest dietary sources of polyphenols: an application of the Phenol-Explorer database. European Journal of Clinical Nutrition. 2010; 64: 112–120.
Χρήσιμα ενημερωτικά άρθρα (μη επιστημονικά)
• https://europa.eu/youreurope/business/product-requirements/food-labelling/health nutrition-claims/index_el.htm
• https://www.onmed.gr/diatrofi/story/359777/elaiolado-4-idiotites-poy-epivalloyn-tin kathimerini-katanalosi-toy
• https://medlabgr.blogspot.com/2012/11/blog-post_26.html#gsc.tab=0 • https://healthia.gr/elaiolado-diatrofiki-axia-idiotites-kai-ofeli/
• https://www.iatropedia.gr/ygeia/i-magikes-therapeftikes-idiotites-tou-ellinikou eleoladou/28946/
• https://www.mednutrition.gr/portal/efarmoges/leksiko-diatrofis/12775-omo-elaiolado polytimo-gia-tin-ygeia-kai-gia-tin-kouzina-mas
• https://www.ypaithros.gr/sinaspizontai-oi-ellines-paragwgoi-elaioladwn-me igeioprostateutiki-drasi/
• https://www.dimotikiagoratislakonias.gr/epikairotita/ygeia/item/41964-ta-apotelesmata klinikis-meletis-me-elaiolado-sto-nosokomeio-spartis